Related Experiment Videos
Single site-modified congeners of vinblastine dissociate its various anti-microtubule actions
L S Borman1, M E Kuehne, P A Matson
1Department of Pharmacology, University of Vermont, Burlington.
The Journal of Biological Chemistry
|May 25, 1988
Abstract:
New C-20' alkyl congeners of vinblastine (VBL) were examined for their reaction with purified microtubule protein or steady-state microtubules in vitro. We found that each of the three typical activities of VBL with this system was amenable to alteration through structural modification of the molecule at this single site. The activity profiles were congener-specific, and they establish the dissociable nature of the various actions that characterize the parent molecule, VBL.