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Inhaled nitric oxide reduces the intrapulmonary shunt to ameliorate severe hypoxemia after acute type A aortic

Guang-Wei Hao¹, Guo-Wei Tu¹, Shen-Ji Yu²

¹Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.

Nitric Oxide : Biology and Chemistry

|March 5, 2021

Abstract

Background:

To assess the relationship between the intrapulmonary shunt and PaO₂/FiO₂ in severe hypoxemic patients after acute type A aortic dissection (ATAAD) surgery and to evaluate the effect of inhaled nitric oxide (iNO) on intrapulmonary shunt.

Methods:

Postoperative ATAAD patients with PaO₂/FiO₂ ≤ 150 mmHg were enrolled. Intrapulmonary shunt was calculated from oxygen content of different sites (artery [CaO₂], mixed venous [CvO₂], and alveolar capillary [CcO₂]) using the Fick equation, where intrapulmonary shunt = (CcO₂-CaO₂)/(CcO₂-CvO₂). Related variables were measured at baseline (positive end expiratory pressure [PEEP] 5 cm H₂O), 30 min after increasing PEEP (PEEP 10 cm H₂O), 30 min after 5 ppm iNO therapy (PEEP 10 cm H₂O + iNO), and 30 min after decreasing PEEP (PEEP 5 cm H₂O + iNO).

Results:

A total of 20 patients were enrolled between April 2019 and December 2019. Intrapulmonary shunt and PaO₂/FiO₂ were correlated in severe hypoxemic, postoperative ATAAD patients (adjusted R² = 0.467, p < 0.001). A mixed model for repeated measures revealed that iNO, rather than increasing PEEP, significantly decreased the intrapulmonary shunt (by 15% at a PEEP of 5 cm H₂O and 16% at a PEEP of 10 cm H₂O, p < 0.001 each) and increased PaO₂/FiO₂ (by 63% at a PEEP of 5 cm H₂O and 65% at a PEEP of 10 cm H₂O, p < 0.001 each). After iNO therapy, the decrement of intrapulmonary shunt and the increment of PaO₂/FiO₂ were also correlated (adjusted R² = 0.375, p < 0.001).

Conclusions:

This study showed that intrapulmonary shunt and PaO₂/FiO₂ were correlated in severe hypoxemic, postoperative ATAAD patients. Furthermore, iNO, rather than increasing PEEP, significantly decreased the intrapulmonary shunt to improve severe hypoxemic conditions.

Keywords:

Aortic dissection Hypoxemia Inhaled nitric oxide Intrapulmonary shunt

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