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Updated: Nov 15, 2025
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
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CCR5Δ32 mutations do not determine COVID-19 disease course
Stefanie N Bernas1, Henning Baldauf2, Sarah Wendler2
1DKMS, Tübingen, Germany.
Summary
The CCR5-delta 32 genetic mutation does not impact the risk of contracting SARS-CoV-2 or developing severe COVID-19. This study found no significant difference in infection rates or disease severity based on CCR5Δ32 status.
Area of Science:
- Genetics
- Virology
- Immunology
Background:
- The C-C chemokine receptor 5 (CCR5) plays a role in immune responses.
- A specific deletion mutation, CCR5Δ32, affects CCR5 function.
- Understanding genetic factors influencing SARS-CoV-2 susceptibility is crucial.
Purpose of the Study:
- To investigate the association between the CCR5Δ32 mutation and the risk of SARS-CoV-2 infection.
- To evaluate the impact of CCR5Δ32 on the severity of COVID-19 disease.
- To determine if CCR5Δ32 influences the likelihood of symptomatic infection, severe respiratory tract infection, or hospitalization.
Main Methods:
- A cross-sectional study was conducted using data from stem cell donors in Germany.
- Genetic information (CCR5Δ32 status) was linked to self-reported COVID-19 outcomes.
- Multivariable regression models analyzed the risk of SARS-CoV-2 infection and disease severity.
Main Results:
- Data from 110,544 donors were analyzed for SARS-CoV-2 infection.
- No significant difference in SARS-CoV-2 infection risk was observed between individuals with and without the CCR5Δ32 mutation (OR 0.96, P=0.21).
- CCR5Δ32 status did not significantly affect the risk of symptomatic infection, severe respiratory tract infection, or hospitalization.
Conclusions:
- The CCR5Δ32 mutation does not appear to be a determinant factor for SARS-CoV-2 infection.
- The CCR5Δ32 genotype does not influence the clinical course or severity of COVID-19.
- Genetic variations like CCR5Δ32 may not play a significant role in SARS-CoV-2 susceptibility or disease progression.
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