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Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis

Dominika Ambrożej1,2, Karolina Dumycz1,2, Piotr Dziechciarz3

  • 1Department of Pediatric Pneumonology and Allergy, Medical University of Warsaw, 02-091 Warsaw, Poland.

Nutrients
|March 6, 2021
PubMed

Insights

Milk fat globule membrane (MFGM) supplementation in infant formula is safe and shows potential benefits for infant growth, mirroring breast milk effects. Further research is needed to confirm promising impacts on immunity and cognition.

Area of Science:

  • Pediatrics
  • Nutrition Science
  • Immunology

Background:

  • Milk fat globule membrane (MFGM) is crucial for lipid transport in breast milk and possesses immunological and antimicrobial properties.
  • Standard infant formulas lack MFGM due to processing, potentially missing key bioactive components.
  • MFGM supplementation in infant formula aims to replicate breast milk's benefits.

Purpose of the Study:

  • To evaluate the safety and efficacy of MFGM supplementation in infant formulas.
  • To compare growth parameters and other health outcomes in infants receiving MFGM-supplemented formula versus standard formula or breast milk.

Main Methods:

  • A systematic literature search was conducted across four databases for randomized controlled trials.
  • Seventeen studies involving 24 publications were included in the meta-analysis.
  • Primary outcomes focused on growth parameters at 4 months of age.

Main Results:

  • MFGM-supplemented formulas demonstrated non-inferior growth compared to standard formulas.
  • Infant growth outcomes in MFGM-supplemented formulas were more similar to those of breastfed infants.
  • No significant adverse effects were reported, indicating a good safety profile.

Conclusions:

  • MFGM supplementation in infant formula appears safe and may offer beneficial effects.
  • Promising findings regarding reduced acute otitis media and enhanced cognitive development require further investigation.
  • Well-designed clinical trials are necessary to definitively establish the benefits of MFGM supplementation.

Keywords:
MFGMchildrenfeedinginfant formulamilk fat globule membrane

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