Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Posture Tracking of Active Capsule Endoscopes Integrated with Magnetic Actuation Using Hall-Effect Sensors.

Micromachines·2026
Same author

Non-invasive hemodynamic monitoring during hemorrhage and blood transfusion: opportunities and challenges.

Physiological measurement·2026
Same author

Unsupervised Variational-Autoencoder-Based Analysis of Morphological Representations in Magnetic-Nanoparticle-Treated Macrophages.

Bioengineering (Basel, Switzerland)·2026
Same author

Secure Angle-Based Geometric Elimination (SAGE) for Microrobot Path Planning.

Micromachines·2025
Same author

Stiffening iron particles to modulate physical interactions.

Nature communications·2025
Same author

Parametric Rule-Based Intelligent System (PRISM) for Design and Analysis of High-Strength Separable Microneedles.

Micromachines·2025

Related Experiment Video

Updated: Nov 15, 2025

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
06:51

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations

Published on: August 21, 2018

7.3K

Micromotor Manipulation Using Ultrasonic Active Traveling Waves.

Hiep Xuan Cao1,2, Daewon Jung1, Han-Sol Lee1,2

  • 1Korea Institute of Medical Microrobotics, Gwangju 506813, Korea.

Micromachines
|March 6, 2021
PubMed
Summary

This study demonstrates a new ultrasonic transducer array for precise 3D manipulation of micro-objects in fluids. This technology shows promise for targeted drug delivery applications within the human body.

Keywords:
acoustic manipulationactive traveling wavenon-contact manipulationparticle manipulationtargeted drug deliveryultrasonic actuation

More Related Videos

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics
12:26

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Published on: August 27, 2013

17.5K
Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels
08:32

Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels

Published on: January 28, 2022

2.6K

Related Experiment Videos

Last Updated: Nov 15, 2025

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
06:51

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations

Published on: August 21, 2018

7.3K
Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics
12:26

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Published on: August 27, 2013

17.5K
Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels
08:32

Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels

Published on: January 28, 2022

2.6K

Area of Science:

  • Biomedical Engineering
  • Acoustic Manipulation
  • Nanotechnology

Background:

  • Efficient targeted drug delivery requires precise manipulation of therapeutic agents.
  • Ultrasonic manipulation offers potential for trapping and guiding micro-scale objects in fluids.
  • Traveling wave ultrasonic manipulation shows advantages for in vivo applications.

Purpose of the Study:

  • To present a novel hemispherical ultrasonic transducer (UT) array for active traveling wave generation.
  • To demonstrate the manipulation of a micromotor in 3D space using phase modulation.
  • To validate the feasibility of this ultrasonic manipulation system for potential in vivo applications.

Main Methods:

  • A novel hemispherical UT array with 16 transducers operating at 1 MHz was designed and fabricated.
  • Active traveling waves were generated using independent phase modulation of each transducer.
  • In vitro and ex vivo experiments were conducted to demonstrate micromotor manipulation and twin trap generation.

Main Results:

  • The UT array successfully generated active traveling waves for micromotor manipulation in water.
  • Independent phase control enabled the creation of a twin trap for precise 3D manipulation.
  • Feasibility was confirmed through successful in vitro and ex vivo experimental demonstrations.

Conclusions:

  • The developed ultrasonic manipulation device using active traveling waves is a versatile tool.
  • This technology offers precise control for manipulating micro-objects in 3D space.
  • Potential applications include targeted drug delivery via in vivo micromotor manipulation.