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Alterations of Extracellular Matrix Components in the Course of Juvenile Idiopathic Arthritis

Magdalena Wojdas1, Klaudia Dąbkowska1, Katarzyna Winsz-Szczotka1

  • 1Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, ul. Jedności 8, 41-200 Sosnowiec, Poland.

Metabolites
|March 6, 2021
PubMed

Insights

Juvenile idiopathic arthritis (JIA) involves joint damage due to inflammation and altered extracellular matrix (ECM) metabolism. Reviewing catabolic factors in children with JIA may reveal new diagnostic and therapeutic strategies.

Area of Science:

  • Rheumatology
  • Pediatric Medicine
  • Biochemistry

Background:

  • Juvenile idiopathic arthritis (JIA) is a prevalent chronic childhood connective tissue disease.
  • Inflammation and proinflammatory cytokines drive articular cartilage destruction in JIA.
  • Disrupted extracellular matrix (ECM) homeostasis underlies progressive joint damage.

Purpose of the Study:

  • To review enzymatic and non-enzymatic factors in ECM component catabolism.
  • To examine molecules that stimulate ECM component biosynthesis.
  • To discuss the diagnostic potential of these factors in JIA disease activity assessment.

Main Methods:

  • Literature review of enzymatic and non-enzymatic factors.
  • Analysis of ECM component metabolism in JIA.
  • Evaluation of potential biomarkers in body fluids.

Main Results:

  • JIA involves dysregulated ECM metabolism, impacting proteoglycans and cartilage.
  • Specific catabolic factors and biosynthesis regulators are altered in JIA.
  • Changes in these factors in body fluids show potential for disease assessment.

Conclusions:

  • Understanding ECM changes in JIA is crucial for developing new diagnostic tools.
  • Identifying key factors in ECM metabolism may lead to novel therapeutic strategies for JIA.
  • Biomarkers related to ECM turnover could improve JIA management.

Keywords:
extracellular matrixjuvenile idiopathic arthritismatrix metalloproteinasesproteoglycansreactive oxygen species

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