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COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences

Luis Sanchez-Russo1, Marzuq Billah1, Jorge Chancay1

  • 1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Journal of Clinical Medicine
|March 6, 2021
PubMed

Insights

Acute kidney injury (AKI) in COVID-19 patients, or CoV-AKI, is common and linked to higher mortality. Management challenges include increased demand for kidney replacement therapies and exploring novel treatments like peritoneal dialysis.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Acute kidney injury (AKI) is a frequent complication of COVID-19.
  • COVID-19-related AKI (CoV-AKI) is associated with increased mortality.
  • The exact causes of CoV-AKI are still under investigation, with evidence suggesting direct viral and indirect injury to the kidneys.

Purpose of the Study:

  • To highlight the clinical presentation and management challenges of CoV-AKI.
  • To discuss the impact of CoV-AKI on healthcare systems, particularly kidney replacement therapies.
  • To explore alternative treatment strategies for critically ill patients with CoV-AKI.

Main Methods:

  • Review of existing literature on CoV-AKI.
  • Analysis of histopathologic findings in COVID-19 patients with kidney injury.
  • Discussion of clinical observations and therapeutic approaches, including acute peritoneal dialysis.

Main Results:

  • CoV-AKI significantly increases mortality risk in COVID-19 patients.
  • The high incidence of CoV-AKI strains healthcare resources for kidney replacement therapies.
  • Alternative treatments like peritoneal dialysis are being explored for severe cases.

Conclusions:

  • CoV-AKI presents significant clinical and resource challenges.
  • Long-term outcomes for survivors of CoV-AKI remain a concern, with a notable proportion requiring ongoing kidney support.
  • Healthcare professionals must be prepared to manage CoV-AKI to mitigate its impact on patients and renal services.

Keywords:
AKIATICGCKDCOVID-19CoV-AKIESKD

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