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Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical

Futaba Inoue1, Kenbun Sone1, Yusuke Toyohara1

  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, Japan.

International Journal of Molecular Sciences
|March 6, 2021
PubMed

Insights

Epigenetic changes like DNA methylation are key in endometrial cancer development. This review covers their role, diagnostic tools, and emerging epigenetic drugs in trials.

Area of Science:

  • Gynecological Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Endometrial cancer is a common gynecological malignancy with poor prognosis in advanced stages.
  • Limited treatment options exist for recurrent endometrial cancer.
  • Epigenetic dysregulation, including DNA methylation and histone modification, is implicated in various cancers.

Purpose of the Study:

  • To review the role of DNA methylation and histone modification in endometrial cancer.
  • To discuss diagnostic tools for these epigenetic modifications.
  • To summarize epigenetic inhibitors in preclinical and clinical development for endometrial cancer.

Main Methods:

  • Literature review focusing on DNA methylation and histone modification in endometrial cancer.
  • Analysis of current diagnostic techniques for epigenetic alterations.
  • Survey of ongoing preclinical and clinical trials for epigenetic drugs.

Main Results:

  • Epigenetic dysregulation, particularly DNA methylation and histone modification, significantly contributes to endometrial cancer initiation and progression.
  • Various diagnostic tools are available to detect these epigenetic changes.
  • Several inhibitors targeting epigenetic regulators are under investigation in preclinical and clinical settings.

Conclusions:

  • Epigenetic modifications play a crucial role in endometrial cancer.
  • Diagnostic advancements aid in understanding these changes.
  • Targeting epigenetic regulators offers promising therapeutic strategies for endometrial cancer.
Keywords:
DNA methylationendometrial cancerepigeneticshistone acetylationhistone methylationhistone modification

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