Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hodgkin's disease: a flow cytometric study.

K G Morgan1, P Quirke, C J O'Brien

  • 1Department of Pathology, University of Leeds.

Journal of Clinical Pathology
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The observation of starch digestion in blue mussel Mytilus galloprovincialis exposed to microplastic particles under varied food conditions.

PloS one·2021
Same author

Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation.

Experimental eye research·2020
Same author

The Haemostatic Mechanism and Menstruation: The Role of Intra-Uterine Contraceptive Devices.

Thrombosis and haemostasis·2019
Same author

Yorkshire Case Control Study of Leukaemias and Lymphomas Parallel Multivariate Analyses of Seven Disease Categories.

Leukemia & lymphoma·2016
Same author

Modulating non-native aggregation and electrostatic protein-protein interactions with computationally designed single-point mutations.

Protein engineering, design & selection : PEDS·2016
Same author

Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.

Pharmacological reviews·2016
Same journal

HER2-low as a unique subgroup in breast cancer: insights from neoadjuvant chemotherapy response and survival analysis.

Journal of clinical pathology·2026
Same journal

Polyp-forming Dieulafoy lesion of the rectum.

Journal of clinical pathology·2026
Same journal

Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

Journal of clinical pathology·2026
Same journal

MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

Journal of clinical pathology·2026
Same journal

Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

Journal of clinical pathology·2026
Same journal

MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

Journal of clinical pathology·2026
See all related articles

Flow cytometry analysis of Hodgkin's disease revealed aneuploid tumors in 11% of cases. While a trend towards better survival was observed for aneuploid tumors and those with a lower proliferative index, these findings were not statistically significant.

Area of Science:

  • Hematology
  • Oncology
  • Cell Biology

Background:

  • Hodgkin's disease is a lymphoma with diverse histological subtypes.
  • Understanding tumor cell proliferation and ploidy is crucial for prognostic assessment.

Purpose of the Study:

  • To investigate the prevalence of aneuploidy and the median proliferative index in Hodgkin's disease.
  • To explore the correlation between ploidy, proliferative index, histological subtypes, and patient survival.

Main Methods:

  • Flow cytometry was utilized to analyze paraffin-embedded tissue samples from 115 Hodgkin's disease cases.
  • Tumor ploidy and proliferative index were quantified.

Main Results:

  • Aneuploidy was detected in 13% (11%) of Hodgkin's disease tumors, with no significant difference across histological subgroups.

Related Experiment Videos

  • The median proliferative index was 14%, with higher values noted in the NS2 and lymphocyte-depleted subgroups.
  • Trends suggested better survival for aneuploid tumors and those with a proliferative index <15%, though not statistically significant.

    • Conclusions:

    • Aneuploidy and proliferative index show variable distribution across Hodgkin's disease subtypes.
    • While trends indicate potential prognostic value, further research is needed to establish the significance of these markers for patient survival.