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Updated: Nov 15, 2025

Probiotic Studies in Neonatal Mice Using Gavage

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

When a Neonate Is Born, So Is a Microbiota.

Alessandra Coscia¹, Flaminia Bardanzellu², Elisa Caboni²

¹Neonatology Unit, Department of Public Health and Pediatrics, Università degli Studi di Torino, 10124 Turin, Italy.

Life (Basel, Switzerland)

|March 6, 2021

Summary

The human microbiota, established before birth, significantly impacts lifelong health. Maternal health and perinatal factors like delivery mode and nutrition shape this crucial early bacterial colonization.

Keywords:

breastfeeding delivery microbiome neonatal microbiota neonatal nutrition perinatal programming placenta

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Last Updated: Nov 15, 2025

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Published on: January 27, 2019

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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Area of Science:

Microbiology
Human Microbiome Research
Perinatal Health

Background:

The human body hosts a unique microbiota from fetal development onwards.
Early life microbial colonization influences long-term health and well-being.
Maternal health and habits significantly impact fetal and neonatal microbiota.

Purpose of the Study:

To review pre- and perinatal factors influencing neonatal microbiota.
To highlight the impact of early microbiota on lifelong health.
To emphasize the role of maternal and neonatal factors in shaping the microbiome.

Main Methods:

Narrative review of existing literature.
Analysis of studies on maternal and neonatal microbiota.
Synthesis of data on factors influencing microbial colonization.

Main Results:

Human microbiota colonization begins during fetal life, not after birth.
Maternal genital microbiota influences fertility and pregnancy outcomes.
Delivery mode, nutrition (e.g., breastfeeding), and drug administration affect neonatal microbiota.

Conclusions:

Pre- and perinatal factors critically shape the neonatal microbiome.
Early life microbial exposure has lasting effects on offspring health.
Understanding these factors is key to optimizing infant health through microbiome modulation.