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Thyroid Carcinoma: Phenotypic Features, Underlying Biology and Potential Relevance for Targeting Therapy
Jinwei Hu1, Isabella J Yuan1, Saied Mirshahidi2
1Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.
International Journal of Molecular Sciences
|March 6, 2021
Summary
This review explores thyroid carcinoma heterogeneity, highlighting genetic and epigenetic factors. Understanding these complexities aids in developing novel targeted therapies for improved treatment outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Thyroid carcinoma is phenotypically diverse.
- Advances in biological technologies are revealing factors contributing to cancer heterogeneity.
Purpose of the Study:
- To review recent findings on thyroid cancer biology and heterogeneity.
- To identify novel therapeutic targets based on new biological insights.
- To discuss the role of intratumor heterogeneity in therapeutic resistance.
Main Methods:
- Literature review of recent advances in thyroid cancer research.
- Analysis of genetic, epigenetic, and non-genetic factors.
- Examination of cancer stemness and tumor microenvironment.
Main Results:
- New findings are improving the understanding of thyroid cancer biology.
- Genetic and epigenetic factors are critical contributors to heterogeneity.
- Intratumor heterogeneity is relevant to therapeutic resistance.
Conclusions:
- Understanding thyroid cancer heterogeneity is key to developing targeted therapies.
- Novel therapeutic strategies can be designed based on recent discoveries in tumor biology.
Keywords:
cancer stem cellsepigeneticsgeneticsheterogeneitytargeting therapythyroid carcinomatumor microenvironmentsMore Related Videos
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