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MR imaging with Gd-DTPA in leptomeningeal spread of lymphoma

D H Berns1, S Blaser, J S Ross

  • 1Department of Radiology, University Hospitals of Cleveland, OH 44106.

Journal of Computer Assisted Tomography
|May 1, 1988
PubMed

Insights

Magnetic resonance imaging (MRI) with gadolinium-diethylenetriamine pentaacetic acid (DTPA) contrast enhanced the diagnosis of leptomeningeal spread of lymphoma. This contrast agent provided crucial information, improving diagnostic accuracy in suspected neoplastic meningitis.

Area of Science:

  • Neurology
  • Radiology
  • Oncology

Background:

  • Leptomeningeal spread of lymphoma presents diagnostic challenges.
  • Noncontrast magnetic resonance imaging (MRI) may not always provide sufficient detail.
  • Early and accurate diagnosis is crucial for effective patient management.

Observation:

  • A case study detailing magnetic resonance (MR) findings in a patient with confirmed leptomeningeal lymphoma spread.
  • The study specifically examined the utility of gadolinium-diethylenetriamine pentaacetic acid (DTPA) contrast enhancement.
  • Comparison of noncontrast MR images with contrast-enhanced MR images was performed.

Findings:

  • Gadolinium-DTPA enhanced MR imaging provided additional diagnostic information beyond noncontrast studies.
  • The contrast agent helped to better delineate the extent of leptomeningeal neoplastic involvement.
  • This facilitated a more confident diagnosis of leptomeningeal spread.

Implications:

  • Contrast-enhanced MR imaging with Gd-DTPA is a valuable tool in diagnosing leptomeningeal spread of neoplasms.
  • It can serve as an important adjunct in the work-up of patients with suspected leptomeningeal disease.
  • Improved diagnostic capabilities may lead to earlier therapeutic interventions and better patient outcomes.

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