Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Piceatannol as a safe senotherapeutic: ameliorating senescence-associated markers in a radiation-induced murine model.

Cell death discovery·2026

Same author

Mitogenome Characterization and Phylogenetic Insights Into Blind Mole Rats, <i>Nannospalax nehringi,</i> and <i>N. turcicus</i>, From Türkiye.

Ecology and evolution·2026

Same author

A Comprehensive Summary of the Third International StemNet Meeting 2026.

Frontiers in bioscience (Landmark edition)·2026

Same author

Biotechnologically Derived Materials as Drug Delivery Systems for Tissue Regeneration.

Frontiers in bioscience (Elite edition)·2026

Same author

Agro-Industrial Plant Biomass as a Sustainable Source of Anticancer Polyphenols: Molecular Mechanisms and Future Perspectives.

Current issues in molecular biology·2026

Same author

A conserved regulatory architecture stabilizes cellular senescence across distinct triggers in human fibroblasts.

GeroScience·2026

Search research articles

Related Experiment Video

Updated: Nov 15, 2025

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Published on: October 4, 2013

Why Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysis.

Mustafa B Acar^1,2, Domenico Aprile³, Serife Ayaz-Guner⁴

¹Graduate School of Natural and Applied Sciences, Erciyes University, Kayseri 38039, Turkey.

International Journal of Molecular Sciences

|March 6, 2021

Summary

Multipotent progenitor cells (Muse) are adult stem cells that resist genotoxic stress. Their unique proteomic pathways, including ubiquitin degradation and reactive oxygen scavenging, explain their remarkable stress tolerance for cell therapy applications.

Keywords:

DNA damage mesenchymal stromal cells oxidative stress stem cells

More Related Videos

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Measurements of Physiological Stress Responses in C. Elegans

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

Related Experiment Videos

Last Updated: Nov 15, 2025

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Published on: October 4, 2013

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Measurements of Physiological Stress Responses in C. Elegans

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

Area of Science:

Stem Cell Biology
Proteomics
Cellular Stress Response

Background:

Muse cells are adult stem cells with inherent resistance to genotoxic stress.
Their unique properties suggest potential as alternatives to mesenchymal stromal cells (MSCs) and induced pluripotent stem cells (iPSCs) in cell therapy.
Muse cells demonstrate survival in adverse microenvironments, such as damaged tissues.

Purpose of the Study:

To investigate the proteome of Muse cells under basal and oxidative stress conditions.
To compare the proteomic profiles of Muse cells with those of iPSCs and MSCs.
To identify key biological pathways and networks contributing to Muse cell stress resistance.

Main Methods:

Proteomic analysis of Muse cells, iPSCs, and MSCs.
Evaluation under basal conditions and following oxidative stress treatment.
Bioinformatic analysis to identify enriched ontologies, pathways, and protein-protein interaction networks.

Main Results:

Muse cells exhibit enrichment in pathways related to endosomal vacuolar trafficking, stress response, ubiquitin-proteasome degradation, and reactive oxygen scavenging.
Key nodes in the Muse cell protein-protein interaction network include NFKB (involved in apoptosis protection) and CRKL (part of the stress-activated protein kinase pathway).
These identified pathways are crucial for cellular component quality control.

Conclusions:

The proteomic profile of Muse cells provides molecular insights into their exceptional stress resistance.
Pathways involved in cellular quality control and stress response mechanisms underpin Muse cell resilience.
These findings support the potential of Muse cells in cell therapy, particularly in challenging therapeutic environments.