Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Genetic Landscape of Fibrotic Interstitial Lung Diseases: Clinical Implications and Diagnostic Challenges in Familial Pulmonary Fibrosis.

Journal of clinical medicine·2026
Same author

Quality of maternal and newborn care, perinatal mental health and the emotional birth experience of women: findings of the IMAgiNE EURO study in Belgium.

BMJ open·2026
Same author

GLO1 cg26053840 Methylation Associates with Kidney Injury and Inflammatory Markers in Hospitalized Older Adults.

Life (Basel, Switzerland)·2026
Same author

MicroRNAs and predicted targets in the switch from monolayered to spheroids of cholangiocarcinoma cells.

Experimental and molecular pathology·2026
Same author

B-cell DNA methylation signature in response to hepatitis B virus vaccination in females and males.

Frontiers in immunology·2026
Same author

Methodological considerations in randomized trial of third trimester ultrasound screening (reply to letter to the editor).

American journal of obstetrics and gynecology·2026

Related Experiment Video

Updated: Nov 15, 2025

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.9K

Extensive Placental Methylation Profiling in Normal Pregnancies.

Ornella Rondinone1, Alessio Murgia1, Jole Costanza1

  • 1Research Laboratories Coordination Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

International Journal of Molecular Sciences
|March 6, 2021
PubMed
Summary

Placental DNA methylation patterns are vital for fetal growth. Unique placental methylation profiles may reflect environmental adaptations, with differences linked to birth weight and potential cancer pathway associations.

Keywords:
LINE-1birth weightmethylomenormal pregnanciesplacenta

More Related Videos

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

9.9K
Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

3.2K

Related Experiment Videos

Last Updated: Nov 15, 2025

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.9K
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

9.9K
Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

3.2K

Area of Science:

  • Epigenetics
  • Developmental Biology
  • Genomics

Background:

  • Placental methylation regulates genes essential for trophoblast invasion and fetal growth.
  • Understanding placental epigenetic regulation is key to fetal development.

Purpose of the Study:

  • Investigate LINE-1 methylation and genome-wide methylation profiles in human placentae.
  • Correlate methylation patterns with birth weight percentiles in normal, full-term pregnancies.

Main Methods:

  • Analyzed DNA methylation using methylation EPIC array and targeted sequencing in 154 pregnancies.
  • Stratified samples by birth weight percentiles.
  • Compared placental methylation with cord blood methylation profiles.

Main Results:

  • LINE-1 hypomethylation was more pronounced in small for gestational age neonates.
  • Placentae exhibited highly variable, unique methylation profiles, unlike stable cord blood profiles.
  • Placental hypermethylation was linked to blood-specific functions, while hypomethylation was associated with cancer pathways.

Conclusions:

  • Unique placental methylation profiles may represent adaptive adjustments during pregnancy.
  • Placental methylation dynamics are crucial for understanding its plasticity and response to environmental factors.
  • Functional similarities exist between placental and cancer epigenetics.