Jove
Visualize
Contact Us

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

823
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
823
Seizures: Classification01:13

Seizures: Classification

911
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
911
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

603
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
603

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serofast Syphilis Is Associated with Phospholipid-Dependent Coagulation Abnormalities and B-Cell Activation Following Treatment.

International journal of molecular sciences·2026
Same author

Artificial Intelligence and Machine Learning in Pediatric Epilepsy: A Systematic Review.

Neurology and therapy·2026
Same author

Acute Disseminated Encephalomyelitis (ADEM): Current View into Etiopathogenesis and Clinical Features.

Brain sciences·2026
Same author

Myoclonus in Pediatric Metabolic Diseases: Clinical Spectrum, Mechanisms, and Treatable Causes-A Systematic Review.

Metabolites·2026
Same author

UV induces common cutaneous amyloid-like melanosomal protein aggregates.

bioRxiv : the preprint server for biology·2025
Same author

The Influence of Pregnancy Risk Factors on Patterns of Sensory Processing Disorders and Motor Development.

Journal of clinical medicine·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 15, 2025

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
09:29

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

3.6K

Neonatal Seizures Revisited.

Konrad Kaminiów1, Sylwia Kozak1, Justyna Paprocka2

  • 1Students' Scientific Society, Department of Pediatric Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.

Children (Basel, Switzerland)
|March 6, 2021
PubMed
Summary

Neonatal seizures, common in newborns, stem from severe central nervous system (CNS) disorders or brain immaturity. Prompt diagnosis and treatment are crucial for better outcomes in infants experiencing these neurological events.

Keywords:
geneticsinborn errors of metabolismneonatal seizurespathophysiology

More Related Videos

Recording EEG in Freely Moving Neonatal Rats Using a Novel Method
08:03

Recording EEG in Freely Moving Neonatal Rats Using a Novel Method

Published on: May 29, 2017

13.6K
Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

28.8K

Related Experiment Videos

Last Updated: Nov 15, 2025

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
09:29

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

3.6K
Recording EEG in Freely Moving Neonatal Rats Using a Novel Method
08:03

Recording EEG in Freely Moving Neonatal Rats Using a Novel Method

Published on: May 29, 2017

13.6K
Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

28.8K

Area of Science:

  • Neonatology
  • Pediatric Neurology
  • Neuroscience

Background:

  • Neonatal seizures are the most common neurological disorder in newborns.
  • They often indicate severe central nervous system (CNS) disorders or immature brain development.
  • Causes include hypoxic-ischemic encephalopathy (HIE), stroke, hemorrhage, infections, and metabolic disturbances.

Purpose of the Study:

  • To review the latest findings on the etiology and pathomechanism of neonatal seizures.
  • To outline clinical symptoms and current management guidelines for acute symptomatic seizures in neonates.
  • To emphasize the importance of timely diagnosis and treatment for improving infant outcomes.

Main Methods:

  • Literature review of recent reports on neonatal seizures.
  • Synthesis of information on causes, mechanisms, symptoms, and treatment strategies.
  • Analysis of current clinical guidelines for managing neonatal seizures.

Main Results:

  • Identified key causes of neonatal seizures, including HIE, stroke, intracranial hemorrhage, CNS infections, and electrolyte imbalances.
  • Detailed the clinical presentation and underlying pathomechanisms.
  • Highlighted the variability in prognosis and management based on seizure etiology.

Conclusions:

  • Prompt diagnosis and appropriate treatment are critical for mitigating long-term adverse effects and improving outcomes in neonates with seizures.
  • Understanding the specific etiology is essential for effective therapeutic management.
  • This review provides an updated overview for clinicians managing this vulnerable population.