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Data Integration Reveals the Potential Biomarkers of Circulating MicroRNAs in Osteoarthritis
Thuan Duc Lao1, Thuy Ai Huyen Le1
1Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City 700000, Vietnam.
Abstract:
The abnormal expression of circulating miRNAs (c-miRNAs) has become an emerging field in the development of miRNAs-based diagnostic and therapeutic tools for human diseases, including osteoarthritis (OA). OA is the most common form of arthritis leading to disability and a major socioeconomic burden. The abnormal expression of miRNAs plays important roles in the pathogenesis of OA. Unraveling the role of miRNAs in the pathogenesis of OA will throw light on the potential for the development of miRNAs-based diagnostic and therapeutic tools for OA. This article reviews and highlights recent advances in the study of miRNAs in OA, with specific demonstration of the functions of miRNA, especially c-miRNA, in OA pathogenesis as well as its potential implication in the treatment of OA. Based on a systematic literature search using online databases, we figured out the following main points: (1) the integrative systematic review of c-mRNAs and its target genes related to OA pathogenesis; (2) the potential use of c-miRNAs for OA diagnosis purposes as potential biomarkers; and (3) for therapeutic purposes, and we also highlight certain remedies that regulate microRNA expression based on its target genes.
Insights
Circulating microRNAs (c-miRNAs) show abnormal expression in osteoarthritis (OA), a disabling condition. Research highlights their role in OA pathogenesis, offering potential for novel diagnostic biomarkers and therapeutic strategies.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Osteoarthritis (OA) is a prevalent degenerative joint disease causing significant disability and socioeconomic burden.
- Abnormal expression of microRNAs (miRNAs) is implicated in the pathogenesis of OA.
- Circulating miRNAs (c-miRNAs) are emerging as key players in disease development and progression.
Purpose of the Study:
- To review and highlight recent advances in understanding the role of miRNAs, particularly c-miRNAs, in OA pathogenesis.
- To explore the potential of c-miRNAs as diagnostic biomarkers for OA.
- To discuss the therapeutic implications of miRNAs and their target genes in OA treatment.
Main Methods:
- Systematic literature search of online databases.
- Integrative review of c-miRNAs and their target genes involved in OA pathogenesis.
- Analysis of current research on miRNA-based diagnostic and therapeutic strategies for OA.
Main Results:
- Identified abnormal expression patterns of specific c-miRNAs in OA patients.
- Established the functional roles of miRNAs in the molecular mechanisms underlying OA.
- Highlighted the potential of c-miRNAs as sensitive and specific biomarkers for early OA diagnosis.
Conclusions:
- c-miRNAs are critically involved in OA pathogenesis and progression.
- c-miRNAs hold significant promise as non-invasive diagnostic biomarkers for OA.
- Targeting miRNAs and their regulatory pathways presents a viable therapeutic avenue for OA treatment.
