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The Influence of Genetics in Myopia Control: A Pilot Study
Cristina Alvarez-Peregrina1, Miguel Ángel Sánchez-Tena1, Clara Martinez-Perez1
1Department of Pharmacy, Biotechnology, Nutrition, Optics and Optometry, Faculty of Biomedical and Health Science, Universidad Europea de Madrid, 28670 Madrid, Spain.
Journal of Clinical Medicine
|March 6, 2021
Summary
Genetic variants may influence myopia control lens therapy outcomes. The T allele of the rs235770 single-nucleotide polymorphism (SNP) was linked to better treatment response in a pilot study. Larger studies are needed for confirmation.
Area of Science:
- Ophthalmology
- Genetics
- Myopia Control
Background:
- Myopia results from complex genetic and environmental interactions.
- Investigating genetic factors in myopia control treatment response is crucial.
Purpose of the Study:
- To compare allelic and genotypic frequencies of specific single-nucleotide polymorphisms (SNPs) between myopia control treatment responders and non-responders.
- To identify potential genetic markers associated with treatment outcomes for myopia control lenses.
Main Methods:
- Analysis of saliva samples for genetic data from 28 participants in the MiSight Assessment Study Spain (MASS).
- Evaluation of treatment response based on axial length change (< / ≥ 0.22 mm) after two years of MiSight contact lens wear.
- Statistical analysis of SNP frequencies and haplotype analysis using SNPStats and SPSS software.
Main Results:
- The T allele of the rs235770 (BMP2) SNP was significantly associated with a better treatment response (p = 0.019).
- Haplotype analysis revealed significant differences between rs235770…rs1881492 and rs235770-rs1656404 polymorphisms.
- Strong linkage disequilibrium was observed between rs235770 and rs1656404 polymorphisms (r² ≥ 0.54).
Conclusions:
- Genetic variants may influence the effectiveness of myopia control lens therapies.
- This pilot study suggests a potential role for specific SNPs in predicting treatment outcomes.
- Further research with larger sample sizes is required to validate these findings.
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