Graphene and Reproduction: A Love-Hate Relationship

Area of Science:

• Biomedical Engineering
• Reproductive Toxicology
• Nanomaterials Science

Background:

• Graphene and its derivatives have diverse applications, including biomedicine.
• Assessing reproductive toxicity is crucial for understanding nanomaterial safety, including effects on offspring.
• Existing research on graphene's reproductive effects yields varied results.

Purpose of the Study:

• To conduct a scientometric analysis of research on graphene and graphene-based materials in the reproductive field.
• To review in vivo and in vitro studies on the reproductive consequences of graphene material exposure across species.
• To highlight the potential of graphene oxide in improving in vitro fertilization and addressing infertility.

Main Methods:

• Scientometric analysis of published literature.
• Review of in vivo and in vitro experimental studies.
• Focus on diverse animal models, from Archaea to mammals.
• Specific examination of graphene oxide's role in reproductive applications.

Main Results:

• Graphene-based materials exhibit varied toxicological outcomes in reproductive systems.
• Studies indicate potential impacts on reproductive function and offspring health.
• Graphene oxide demonstrates promise in enhancing in vitro fertilization success rates.

Conclusions:

• Graphene materials warrant careful toxicological evaluation concerning reproductive health.
• Graphene oxide presents a potential therapeutic strategy for infertility by improving sperm manipulation and in vitro fertilization.
• Further research is needed to fully elucidate graphene's reproductive effects and optimize its applications.