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Primidone and essential tremor.

S Seyfert1, A Honé, G Holl

  • 1Neurologische Klinik, Klinikum Steglitz, Freie Universität Berlin.

Journal of Neurology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Primidone effectively reduces essential tremor symptoms. A single high dose significantly lowered tremor in most patients, indicating primidone, not just its metabolites, provides therapeutic effects.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Essential tremor is a common neurological disorder.
  • Primidone is a medication used to treat essential tremor, but its active mechanism is debated.
  • It is unclear if primidone's metabolite, phenobarbitone, or primidone itself is responsible for tremor suppression.

Purpose of the Study:

  • To determine if primidone, independent of its metabolites, can suppress essential tremor.
  • To investigate the direct effect of a single high dose of primidone on essential tremor.

Main Methods:

  • A high single dose of primidone was administered to 11 patients with essential tremor.
  • Tremor reduction was measured over time.
  • Serum concentrations of primidone and its metabolites (phenyl-ethyl-malonamide and phenobarbitone) were analyzed.

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Main Results:

  • Eight out of 11 patients experienced a significant reduction in tremor severity (54%-69%) lasting up to 28 hours.
  • Serum levels of primidone were as anticipated, while metabolite levels remained very low.
  • Three patients did not exhibit tremor reduction.

Conclusions:

  • The findings suggest that primidone itself, rather than its metabolites, is responsible for suppressing essential tremor.
  • Primidone demonstrates a direct therapeutic effect on essential tremor symptoms.