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Published on: March 23, 2022
Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow's
Aniek L van Wijngaarden1, Boudewijn P T Kruithof1, Tommaso Vinella2
1Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Abstract:
Degenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency (FED) and Barlow's disease. The aim of this review was to describe the main histological, clinical and echocardiographic features of patients with FED and Barlow's disease, highlighting the differences in diagnosis, risk stratification and patient management, but also the still significant gaps in understanding the exact pathophysiology of these two phenotypes.
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