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Updated: Nov 15, 2025

Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils

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Published on: April 13, 2017

Neuroinflammation in Prion Disease.

Bei Li¹, Meiling Chen¹, Caihong Zhu¹

¹School of Basic Medical Sciences, Fudan University, Dong'An Rd 130, Shanghai 200032, China.

International Journal of Molecular Sciences

|March 6, 2021

Summary

Neuroinflammation, marked by microglial activation and astrogliosis, is key in prion diseases. Targeting these neuroinflammatory processes offers a novel therapeutic strategy for prion and other neurodegenerative disorders.

Keywords:

astrogliosis microglial activation neurodegenerative disease neuroinflammation prion disease

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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

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Published on: January 8, 2015

Area of Science:

Neuroscience
Immunology
Pathology

Background:

Neuroinflammation, characterized by microglial activation and astrogliosis, is a common feature in neurodegenerative diseases like prion diseases.
Microglia exhibit neuroprotective functions, while reactive astrocytes can propagate prions and exacerbate neurodegeneration.
The complex roles of microglia and astrocytes present therapeutic opportunities.

Purpose of the Study:

To investigate the role of neuroinflammation in prion disease pathogenesis.
To explore the dual functions of microglia and astrocytes in prion disease.
To identify neuroinflammation-related molecules as potential therapeutic targets.

Main Methods:

Analysis of microglial activation and astrogliosis.
Transcriptomic alterations in prion disease models.
Identification of neuroinflammation-related molecules involved in pathogenesis.

Main Results:

Microglia demonstrate a primarily neuroprotective role.
Reactive astrocytes with altered phenotypes contribute to prion propagation and neurodegeneration.
Specific neuroinflammation-related molecules are implicated in prion pathogenesis.

Conclusions:

Neuroinflammation is a critical component of prion disease.
Targeting neuroinflammation presents a promising therapeutic avenue for prion diseases.
Understanding neuroinflammation in prion disease can inform strategies for other neurodegenerative disorders.