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Updated: Nov 15, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
Published on: September 28, 2017
Clock at the Core of Cancer Development
Sonal A Patel1,2, Roman V Kondratov2
1Fusion Pharmaceuticals Inc., Hamilton, ON L8P 0A6, Canada.
Circadian clocks regulate biological processes and are linked to cancer. Targeting these clocks offers a new approach to cancer chronotherapy, potentially improving treatment outcomes and reducing side effects.
Area of Science:
- Chronobiology
- Oncology
- Metabolic Signaling
Background:
- Circadian clocks synchronize biological processes with daily cycles.
- These clocks are crucial for regulating physiology and metabolism.
- Circadian disruption is linked to various pathologies, including cancer.
Purpose of the Study:
- To review the role of the circadian clock in regulating the insulin/IGF1/PI3K/mTOR pathway.
- To explore the connection between this pathway's dysregulation and cancer cell proliferation.
- To discuss cancer chronotherapy as a novel treatment strategy.
Main Methods:
- Literature review focusing on circadian clock mechanisms.
- Analysis of the insulin/IGF1/PI3K/mTOR signaling pathway in cancer.
- Synthesis of current research on cancer chronotherapy.
Main Results:
- The circadian clock influences the insulin/IGF1/PI3K/mTOR pathway.
- Dysregulation of this pathway contributes to uncontrolled cancer cell growth.
- Targeting circadian rhythms presents a promising avenue for cancer treatment.
Conclusions:
- Understanding the circadian clock's role in cancer is vital for prevention and treatment.
- Cancer chronotherapy, by targeting circadian rhythms, may enhance traditional therapies.
- This approach holds potential for improved tumor response and reduced treatment toxicity.
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