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The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer

Martina Giuppi1, Anna La Salvia2, Jessica Evangelista3

  • 1Faculty of Medicine, CEU San Pablo University, 28003 Madrid, Spain.

Biology
|March 6, 2021
PubMed

Insights

This review explores angiogenesis-related microRNAs (miRNAs) in gastric cancer (GC). Understanding these miRNAs is crucial for developing new treatments and biomarkers for advanced GC, a disease with poor outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality globally.
  • Current treatments for advanced GC offer limited efficacy, highlighting the need for novel therapeutic strategies.
  • Angiogenesis, the formation of new blood vessels, is critical for GC growth and metastasis.

Purpose of the Study:

  • To review the role of angiogenesis-related microRNAs (miRNAs) in gastric cancer.
  • To identify potential miRNA biomarkers for predicting response to therapies like ramucirumab.
  • To elucidate the molecular mechanisms involving miRNAs in GC angiogenesis.

Main Methods:

  • Comprehensive literature search for studies on angiogenesis and miRNAs in GC.
  • Analysis of existing data on the function of specific miRNAs in GC development and progression.
  • Review of clinical data related to ramucirumab and potential miRNA involvement.

Main Results:

  • Angiogenesis-related miRNAs significantly influence GC cell proliferation, invasion, and migration.
  • Certain miRNAs show potential as predictive biomarkers for anti-angiogenic therapies.
  • Dysregulation of specific miRNAs is implicated in GC pathogenesis and response to treatment.

Conclusions:

  • Angiogenesis-related miRNAs represent a promising area for understanding GC biology.
  • Targeting these miRNAs could offer novel therapeutic avenues for advanced gastric cancer.
  • Further research is needed to validate miRNAs as predictive biomarkers for ramucirumab and other therapies.
Keywords:
Micro RNAs (miRNAs)VEGFangiogenesisbiomarkersgastric cancerramucirumab

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