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The Relationship between Seminal Fluid Hyperviscosity and Oxidative Stress: A Systematic Review
Federica Barbagallo1, Sandro La Vignera1, Rossella Cannarella1
1Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Antioxidants (Basel, Switzerland)
|March 6, 2021
Summary
Seminal fluid hyperviscosity is linked to male infertility due to increased oxidative stress and impaired antioxidant systems. Antioxidant treatment may improve sperm function in affected men.
Area of Science:
- Reproductive Medicine
- Andrology
- Biochemistry
Background:
- Seminal fluid viscosity is crucial for fertilization.
- Increased seminal viscosity is common in infertile men, but the mechanism is unclear.
- Oxidative stress is implicated in other hyperviscosity-related diseases.
Purpose of the Study:
- To investigate the relationship between hyperviscous seminal fluid and oxidative stress in male infertility.
Main Methods:
- Systematic search of PubMed, MEDLINE, Cochrane, and Scopus databases up to January 10, 2021.
- Included studies evaluating the link between increased seminal viscosity and oxidative stress.
- Excluded review articles.
Main Results:
- Five articles were included in the systematic review.
- Patients with high seminal fluid viscosity showed impaired antioxidant systems.
- Increased oxidative stress was observed in men with hyperviscous seminal fluid.
Conclusions:
- Assessment of oxidative stress is clinically valuable for infertile patients with hyperviscous seminal fluid.
- Antioxidant therapy could benefit infertile men with seminal hyperviscosity.
- Antioxidants may protect sperm from oxidative damage and enhance function.
