Related Experiment Video
Updated: Nov 15, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
A Technical Critique of Some Parts of the Free Energy Principle
Martin Biehl1, Felix A Pollock2, Ryota Kanai1
1Araya Inc., Tokyo 107-6024, Japan.
Abstract:
We summarize the original formulation of the free energy principle and highlight some technical issues. We discuss how these issues affect related results involving generalised coordinates and, where appropriate, mention consequences for and reveal, up to now unacknowledged, differences from newer formulations of the free energy principle. In particular, we reveal that various definitions of the "Markov blanket" proposed in different works are not equivalent. We show that crucial steps in the free energy argument, which involve rewriting the equations of motion of systems with Markov blankets, are not generally correct without additional (previously unstated) assumptions. We prove by counterexamples that the original free energy lemma, when taken at face value, is wrong. We show further that this free energy lemma, when it does hold, implies the equality of variational density and ergodic conditional density. The interpretation in terms of Bayesian inference hinges on this point, and we hence conclude that it is not sufficiently justified. Additionally, we highlight that the variational densities presented in newer formulations of the free energy principle and lemma are parametrised by different variables than in older works, leading to a substantially different interpretation of the theory. Note that we only highlight some specific problems in the discussed publications. These problems do not rule out conclusively that the general ideas behind the free energy principle are worth pursuing.
Related Concept Videos
An Introduction to Free Energy
Gibbs Free Energy
Free Energy
Potential-Energy Criterion for Equilibrium
Calculating Standard Free Energy Changes
Free Energy and Equilibrium
The reaction quotient, Q, is a convenient measure of the...

