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Anabolic steroids and aggressive behavior in cynomolgus monkeys
W J Rejeski1, P H Brubaker, R A Herb
1Department of Cardiac Rehabilitation, Wake Forest University, Winston-Salem, North Carolina 27109.
Journal of Behavioral Medicine
|February 1, 1988
Summary
Testosterone administration significantly increased aggression in cynomolgus monkeys. However, social status mediated these behavioral changes, with dominant monkeys exhibiting more aggression than subordinates.
Area of Science:
- Primatology
- Neuroendocrinology
- Behavioral Science
Background:
- Testosterone is a key hormone influencing behavior.
- Aggression is a complex behavior influenced by hormonal and social factors.
- Understanding these influences is crucial for behavioral research.
Purpose of the Study:
- To investigate the impact of testosterone administration on aggressive behavior in a primate model.
- To explore the role of social status in mediating testosterone-induced behavioral changes.
Main Methods:
- Ten cynomolgus monkeys were divided into experimental (testosterone propionate) and control (sham solution) groups.
- Biweekly injections were administered over an 8-week period.
- Behavioral observations, including aggression, were conducted before and after treatment.
Main Results:
- Testosterone administration led to a significant increase in aggressive behaviors.
- The effect of testosterone on aggression was significantly influenced by social hierarchy.
- Dominant monkeys showed a higher frequency of both contact and noncontact aggression compared to subordinate monkeys.
Conclusions:
- Testosterone increases aggression, but its behavioral effects are modulated by social status in primates.
- Social dominance may play a critical role in how individuals respond to hormonal changes.
- Further research is needed to explore the link between anabolic steroids and cardiovascular disease risk.