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Updated: Nov 15, 2025

Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Free Tissue Transfer for Patients with Chronic Lower Extremity Wounds
Jenna C Bekeny1, Elizabeth G Zolper2, John S Steinberg3
1Department of Plastic Surgery, MedStar Georgetown University Hospital, 3800 Reservoir Road Northwest, First Floor PHC Plastic Surgery, Washington, DC 20007, USA. Electronic address: https://twitter.com/JBekeny.
Abstract:
Chronic lower extremity wounds are defined as wounds that fail to heal within 3 months of defect onset. Free tissue transfer offers an opportunity for limb salvage and length preservation. Preoperative optimization includes a medical and nutritional consult, complete work-up by vascular surgery, and an analysis of bony stability and gait biomechanics by podiatric surgery. In the authors' practice, the thigh has proved the workhorse donor site and offers fasciocutaneous and muscle-based flaps depending on defect characteristics. Postoperative care requires early monitoring for flap compromise and continued long-term follow-up for wound recurrence.
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