White Matter Alterations of the Goal-Directed System in Patients With Obsessive-Compulsive Disorder and Their

Ziwen Peng1, Chuanyong Xu1, Ning Ma1

  • 1Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Beijing, China; School of Psychology, Center for Studies of Psychological Application, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China.

Summary

Obsessive-compulsive disorder (OCD) is linked to impaired white matter connectivity in the goal-directed network, affecting learning systems. These white matter changes in the goal-directed network are also seen in unaffected relatives, suggesting it may be an endophenotype of OCD.

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