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The ABCs of ovarian cancer immunology: IgA, B cells, and CTLs

Andrew Lichtman1

  • 1Department of Pathology Brigham and Women's Hospital, 77 Avenue Louis Pasteur Boston, MA, USA.

Science Immunology
|March 6, 2021
PubMed

Intratumoral B cells in ovarian cancers produce IgA, which binds tumor antigens and inhibit tumor growth through myeloid cell-dependent mechanisms or by neutralization of secreted factors, and by antigen-nonspecific binding to poly-Ig receptor on cancer cells leading to transcytosis, which sensitizes the cells for CTL killing.

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