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Published on: July 28, 2022
Spontaneous intestinal perforation in premature infants: a national study
Marwa M Elgendy1, Hasan F Othman2, Farah Heis3
1Department of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USA. elgendm@ccf.org.
Objectives:
To assess the prevalence and outcomes of spontaneous intestinal perforation (SIP) in very low birth weight infants.
Study Design:
This cross-sectional study utilized the National Inpatient Sample dataset for the years 2002-2017. All premature infants with birth weight (BW) <1500 g and with gestational age (GA) ≤32 weeks were included. Analyses were repeated after stratifying the population into two BW sub-categories <1000 g and 1000-1499 g. Trend analysis was done using Cochran-Armitage test. Regression analysis was conducted to control for gestational age, race, and sex.
Result:
A total of 658,001 infants were included. SIP (n = 10,443, 1.6%) was mostly (81.9%) in the category <1000 g with 89.9% ≤28 weeks of gestation. There was a significant trend for increased SIP over the years (p < 0.001). SIP was associated with increased mortality (aOR = 2.24, CI: 2.04-2.46, p < 0.001).
Conclusion:
After controlling for gestational age and other confounders, SIP is associated with increased mortality in premature infants.
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