Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombospondin-2 deficiency primes the synovial joint for aberrant tissue remodeling and injury response.

bioRxiv : the preprint server for biology·2026
Same author

Wnt/β-catenin signaling regulates fibrotic atrophy of intra-articular adipose tissue in post-traumatic osteoarthritis.

bioRxiv : the preprint server for biology·2026
Same author

Decoupling speed matters: Optimizing gait mechanics after anterior cruciate ligament reconstruction with Split-belt adaptation training of the healthy leg.

Clinical biomechanics (Bristol, Avon)·2026
Same author

Spatial transcriptomic profiling of decalcified murine musculoskeletal samples via Xenium Prime 5K.

JBMR plus·2026
Same author

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis.

bioRxiv : the preprint server for biology·2026
Same author

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis-Relevant Pathologic Features in Naïve Murine Knee Joints.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same journal

Multicenter Assessment of Combined Brain and Cervical Spinal cord 3T MP2RAGE T1 Measurements for Reliable Tissue Microstructure Quantification.

NMR in biomedicine·2026
Same journal

Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.

NMR in biomedicine·2026
Same journal

Skeletal Motor Unit Recruitment During Periodic Auditory Cueing: A Simultaneous Behavioral and Motor Unit Magnetic Resonance Imaging (MUMRI) Study.

NMR in biomedicine·2026
Same journal

Quantitative Guanidinium CEST-Based pH Mapping at 3 T in Healthy and Pathological Muscle.

NMR in biomedicine·2026
Same journal

Liver Diffusion Weighted MRI: Effect of Iron Overload on Apparent Diffusion Coefficient.

NMR in biomedicine·2026
Same journal

In Vivo Assessment of Placental Structure and Perfusion in Late-Gestation Pregnancies and Their Association With Fetal Growth.

NMR in biomedicine·2026
See all related articles

Related Experiment Video

Updated: Nov 15, 2025

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
07:57

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

Published on: April 23, 2017

6.4K

An efficient R1ρ dispersion imaging method for human knee cartilage using constant magnetization prepared

Yuxi Pang1, Riann M Palmieri-Smith2,3, Tristan Maerz3

  • 1Department of Radiology, University of Michigan, Ann Arbor, Michigan.

NMR in Biomedicine
|March 6, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces an efficient R1ρ dispersion imaging method for knee cartilage at 3T. The developed protocol shows good repeatability and is robust for clinical studies.

Keywords:
fully refocused spin-lock preparationhuman knee articular cartilagemagic angle effectquantitative R1ρ dispersion imagingtailored constant R1ρ weightingturbo-FLASH

More Related Videos

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.8K
Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
08:12

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Published on: March 20, 2013

12.1K

Related Experiment Videos

Last Updated: Nov 15, 2025

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
07:57

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

Published on: April 23, 2017

6.4K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.8K
Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
08:12

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Published on: March 20, 2013

12.1K

Area of Science:

  • Biomedical Imaging
  • Magnetic Resonance Imaging
  • Cartilage Imaging

Background:

  • Knee cartilage assessment is crucial for diagnosing osteoarthritis.
  • Existing R1ρ imaging methods face challenges in clinical efficiency and robustness.
  • Developing advanced MRI techniques is essential for accurate cartilage evaluation.

Purpose of the Study:

  • To develop an efficient and robust R1ρ dispersion imaging method for clinical studies of human knee cartilage at 3 Tesla (3T).
  • To validate the repeatability and accuracy of the developed method against established techniques.

Main Methods:

  • Developed a novel R1ρ dispersion imaging protocol using tailored spin-lock preparation pulses.
  • Investigated eight constant magnetizations (Mprep) by adjusting pulse duration and amplitude (ω1).
  • Validated the protocol on asymptomatic human knees and compared results with state-of-the-art R1ρ and R2 mapping (MAPSS).

Main Results:

  • The developed protocol demonstrated good repeatability (<5% coefficient of variation) in femoral and tibial cartilage.
  • Synthetic R1ρ and R2 values showed good agreement with published references in femoral and tibial cartilage.
  • Discrepancies were noted in patellar cartilage R1ρ and R2 values compared to references.

Conclusions:

  • The developed R1ρ dispersion imaging scheme is efficient and robust for clinical studies of human knee cartilage at 3T.
  • The method shows promise for improved cartilage assessment in clinical settings.
  • Further refinement may be needed for accurate patellar cartilage evaluation.