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The role of ADRB2 gene polymorphisms in malignancies

Yaqian Wang1, Shujuan Jiang2,3,4

  • 1Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jingwu Road 324#, Jinan, 250021, Shandong, China.

Molecular Biology Reports
|March 6, 2021
PubMed

Insights

Genetic variations in the beta-2 adrenergic receptor (ADRB2) gene influence cancer development and progression. This review explores ADRB2 polymorphisms and their impact on cancer susceptibility, prognosis, and treatment outcomes.

Area of Science:

  • Oncology
  • Pharmacogenomics
  • Molecular Biology

Background:

  • The beta-2 adrenergic receptor (ADRB2) is a G protein-coupled receptor implicated in various cancers.
  • ADRB2 signaling is linked to key cancer hallmarks including proliferation, invasion, and angiogenesis.
  • Expression and function of ADRB2 are modulated by genetic variations within the ADRB2 gene.

Purpose of the Study:

  • To review the clinical significance of ADRB2 gene polymorphisms in malignancies.
  • To elucidate the impact of these polymorphisms on cancer susceptibility, prognosis, and therapeutic response.

Main Methods:

  • Literature review of studies investigating ADRB2 polymorphisms in various cancer types.
  • Analysis of the association between specific ADRB2 single nucleotide polymorphisms (SNPs) and clinical outcomes.
  • Examination of the functional consequences of ADRB2 polymorphisms on receptor expression and sensitivity.

Main Results:

  • Certain ADRB2 polymorphisms are associated with altered cancer risk and patient prognosis.
  • These genetic variations can influence treatment efficacy and resistance in cancer patients.
  • Functional studies demonstrate that ADRB2 SNPs affect receptor expression, signaling, and cellular processes relevant to cancer.

Conclusions:

  • ADRB2 gene polymorphisms represent a significant factor in cancer development and progression.
  • Understanding these pharmacogenetic variations can aid in personalized cancer risk assessment and treatment strategies.
  • Targeting ADRB2 signaling pathways, considering genetic background, may offer novel therapeutic opportunities in oncology.
Keywords:
ADRB2MalignancySingle nucleotide polymorphismβ2-Adrenergic receptor

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