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Updated: Nov 15, 2025

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
Nicolas J Pillon1, Ruth J F Loos2, Sally M Marshall3
1Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Abstract:
The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.
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