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Antimicrobial peptides against colorectal cancer-a focused review

Sonia Chauhan1, Devinder K Dhawan1, Avneet Saini1

  • 1Department of Biophysics, Basic Medical Sciences, Panjab University, Block-II, South Campus, Sector-25, Chandigarh 160014, India.

Pharmacological Research
|March 6, 2021
PubMed

Insights

Antimicrobial peptides (AMPs) show promise for treating colorectal cancer (CRC) by overcoming drug resistance and side effects. Further research and structural modifications are needed for clinical application in CRC therapy.

Area of Science:

  • Biochemistry
  • Oncology
  • Immunology

Background:

  • Colorectal cancer (CRC) treatment faces challenges including drug resistance, metastasis, and chemotherapy side effects.
  • Novel therapeutic strategies are urgently needed to improve patient survival rates and reduce treatment burdens.
  • Antimicrobial peptides (AMPs), components of innate immunity, are being investigated for their potential anticancer properties.

Purpose of the Study:

  • To review the antiproliferative effects of AMPs against colorectal cancer.
  • To explore the potential of AMPs as novel therapeutic agents for CRC.
  • To identify necessary modifications for enhancing AMPs' clinical utility in CRC treatment.

Main Methods:

  • Literature review of scientific reports on AMPs and their action against colon cancer.
  • Analysis of in vitro and in vivo studies investigating AMPs' efficacy.
  • Examination of synthetic and computational techniques for modifying AMPs.

Main Results:

  • AMPs exhibit antiproliferative activity against colorectal cancer cells.
  • AMPs hold potential as standalone or adjunct therapies for CRC.
  • Structural modifications can enhance AMPs' selectivity and pharmacokinetic profiles.

Conclusions:

  • AMP-based therapeutics could become a valuable addition to colorectal cancer treatment strategies.
  • Further research and in vivo studies are required to optimize AMPs for clinical use.
  • Tailoring AMP structures is crucial for their successful integration into modern CRC therapy.
Keywords:
Antimicrobial peptidesAntiproliferativeChemotherapyColorectal cancerTherapeutics

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