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Updated: Nov 15, 2025

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
Published on: January 20, 2012
Attentional processes and contamination-related intrusion distress
Jemma Todd1, Colin MacLeod2, Lies Notebaert2
1Clinical Psychology Unit, School of Psychology, University of Sydney, Sydney, NSW, 2006, Australia; School of Psychological Science, University of Western Australia, Perth, WA, 6009, Australia.
Abstract:
Whilst people with high contamination fear may not experience a greater number of contamination-related intrusions than people with low contamination fear, they tend to experience heightened distress in response to such intrusions. The aim of the present study was to test the hypothesis that attentional bias to contamination-relevant information, and the variability of this attentional bias, moderates the degree to which high contamination fearful but not low contamination fearful individuals experience distress in response to contamination-related intrusions. Individuals with high (n = 31) or low (n = 44) contamination fear completed a lab-based session including questionnaires, a dot-probe measure of contamination-related attentional bias and attentional bias variability, and a contamination stressor video. Participants then completed a week-long contamination intrusions diary. There were significant differences in intrusion distress between those with low and high contamination fear in the anticipated direction, and attentional bias significantly moderated this relationship. Regardless of contamination fear level, greater attentional bias variability was associated with greater intrusion distress. These findings suggest that reducing attentional bias variability could potentially help to reduce distress elicited by contamination-related intrusions, while also highlighting the fact that attentional bias towards threat may protect against such distress in low contamination fearful individuals.
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