Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

2.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.2K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.7K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.7K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

7.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.4K
Stem Cell Niche01:26

Stem Cell Niche

5.7K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.7K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.0K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

15.2K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
15.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a microbiota-humanized mouse model.

Frontiers in immunology·2026
Same author

Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

Molecular cancer therapeutics·2025
Same author

Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8<sup>+</sup> T Cells.

European journal of immunology·2025
Same author

DNA methylation profiling of human CD4<sup>+</sup> T helper cells reveals the epigenetic control of SLAMF7 expression in IFN-γ producing cells.

Immunology and cell biology·2025
Same author

Acsbg1 maintains intestinal immune homeostasis and controls inflammation by regulating ST2<sup>+</sup> Tregs.

Mucosal immunology·2025
Same author

Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses.

Frontiers in immunology·2025

Related Experiment Video

Updated: Nov 15, 2025

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

31.8K

Lymph node stromal cell subsets-Emerging specialists for tailored tissue-specific immune responses.

Mangge Zou1, Carolin Wiechers1, Jochen Huehn2

  • 1Department Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.

International Journal of Medical Microbiology : IJMM
|March 6, 2021
PubMed
Summary

Lymph node stromal cells (LNSCs) are crucial for adaptive immunity, guiding immune cell movement and antigen presentation. Their unique micro-environments tailor tissue-specific immune responses during health and infection.

Keywords:
Immune regulationInfection and inflammationLymph nodeMucosal micro-environmentStromal cells

More Related Videos

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

6.2K
Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

13.9K

Related Experiment Videos

Last Updated: Nov 15, 2025

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

31.8K
Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

6.2K
Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

13.9K

Area of Science:

  • Immunology
  • Cell Biology
  • Anatomy

Background:

  • Adaptive immune responses rely on efficient lymphocyte and antigen trafficking within lymph nodes (LNs).
  • Lymph node stromal cells (LNSCs) were previously considered accessory cells but are now recognized as critical modulators of adaptive immunity.

Purpose of the Study:

  • To review current knowledge on the roles of LNSCs in orchestrating adaptive immune responses.
  • To highlight how micro-environmental cues imprint location-specific information into LNSCs, tailoring immune responses.

Main Methods:

  • Literature review of recent advances in LNSC research.
  • Synthesis of findings on LNSC function in homeostasis and infection.

Main Results:

  • LNSCs play pivotal roles in adaptive immune responses.
  • Micro-environmental cues shape LNSC function, leading to tissue-specific immune tailoring.
  • LNSCs are key regulators of immune cell trafficking and antigen presentation within LNs.

Conclusions:

  • LNSCs are essential cellular players in adaptive immunity, not just accessory cells.
  • Understanding LNSC-mediated tissue-specific immunity is crucial for developing targeted immune therapies.