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Updated: Nov 15, 2025

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison
Published on: October 20, 2020
Discrimination of nano-objects via cluster analysis techniques applied to time-resolved thermo-acoustic microscopy
Andrea Ronchi1, Andrea Sterzi2, Marco Gandolfi3
1Department of Physics and Astronomy, KU Leuven, Celestijnenlaan 200D, 3001 Leuven, Belgium; Interdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, I-25121 Brescia, Italy; Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, I-25121 Brescia, Italy.
Abstract:
Time-effective, unsupervised clustering techniques are exploited to discriminate nanometric metal disks patterned on a dielectric substrate. The discrimination relies on cluster analysis applied to time-resolved optical traces obtained from thermo-acoustic microscopy based on asynchronous optical sampling. The analysis aims to recognize similarities among nanopatterned disks and to cluster them accordingly. Each cluster is characterized by a fingerprint time-resolved trace, synthesizing the common features of the thermo-acoustics response of the composing elements. The protocol is robust and widely applicable, not relying on any specific knowledge of the physical mechanisms involved. The present route constitutes an alternative diagnostic tool for on-chip non-destructive testing of individual nano-objects.

