Related Experiment Video
Updated: Nov 15, 2025
08:23
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
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Hydroxyurea Adherence Strategies for Persons with Sickle Cell Disease: A Systematic Review
Journal of Health Care for the Poor and Underserved
|March 8, 2021
Summary
Hydroxyurea adherence is crucial for managing sickle cell disease. This review found limited evidence on effective strategies, highlighting a need for more research into behavioral interventions for medication adherence.
Area of Science:
- Hematology
- Pharmacology
- Public Health
Background:
- Hydroxyurea is a cornerstone therapy for sickle cell disease (SCD).
- Optimizing adherence to hydroxyurea is critical for disease modification and improved patient outcomes.
- Understanding effective adherence strategies is essential for clinical practice.
Purpose of the Study:
- To systematically review and identify evidence-based strategies supporting hydroxyurea adherence in individuals with SCD.
- To synthesize findings from existing research on interventions aimed at improving medication adherence in SCD patients.
Main Methods:
- A systematic literature search was performed across multiple databases (PubMed, CINAHL, PsycArticles, PsycInfo, Embase, Cochrane Library).
- Studies published between 1998 and 2018 were included.
- Six studies, including RCTs, prospective studies, and a retrospective chart review, met the inclusion criteria.
Main Results:
- The review identified a limited number of studies that specifically tested adherence interventions for hydroxyurea in SCD.
- Interventions primarily focused on behavioral change strategies to enhance medication adherence.
- The evidence base for effective adherence strategies remains sparse.
Conclusions:
- There is a significant gap in research regarding robust strategies to improve hydroxyurea adherence in sickle cell disease.
- Further investigation into behavioral and multifaceted interventions is warranted to support patients on hydroxyurea therapy.
- Future research should focus on developing and evaluating targeted adherence programs for SCD management.
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