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Hydroxyurea Adherence Strategies for Persons with Sickle Cell Disease: A Systematic Review
Introduction:
Adherence to hydroxyurea is essential to modify the pathology of sickle cell disease.
Objective:
To identify best strategies to support adherence to hydroxyurea in persons with sickle cell disease.
Methods:
A systematic review was conducted. PubMed, Cumulative Index of Nursing and Allied Health Literature, PsycArticles, PsycInfo, Embase databases and Cochrane Library were searched for studies between 1998 to 2018.
Results:
Six studies met inclusion criteria: two randomized controlled trials, three prospective studies, and one retrospective chart review.
Discussion:
Few studies addressed strategies that tested adherence interventions primarily composed of behavioral change resulting in medication adherence. More studies on hydroxyurea adherence are needed.
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