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Updated: Nov 15, 2025

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Low dose aspirin is effective in preventing venous thromboembolism in patients undergoing primary total knee
David B Merkow1, Alex Tang1, Richard Iorio2
1Department of Orthopedic Surgery, NYU Langone Health, New York, NY, USA.
Introduction:
Venous thromboembolism (VTE) is a known complication after total knee arthroplasty (TKA) with well-established morbidity, mortality, and significant healthcare expenditure. However, no standard form of prophylaxis against VTE currently exists.
Methods:
A retrospective review was performed identifying 12,866 TKA cases and post-operative VTE events using either 325 mg aspirin or 81 mg aspirin twice daily (BID).
Results:
133 VTE cases were diagnosed of the 9413 TKA on 325 mg aspirin BID compared to 8 VTE cases out of 3453 TKA on 81 mg aspirin BID (1.41% vs. 0.23%, p < 0.001).
Conclusion:
81 mg aspirin BID significantly improved post-operative VTE rates over 325 mg aspirin BID.
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