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The Roles of Envelope Glycoprotein M in the Life Cycle of Some Alphaherpesviruses

Chunmei Li1,2,3, Mingshu Wang1,2,3, Anchun Cheng1,2,3

  • 1Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.

Frontiers in Microbiology
|March 8, 2021
PubMed

Insights

The alphaherpesvirus envelope glycoprotein M (gM) is crucial for viral entry, assembly, and egress. This review details gM

Area of Science:

  • Virology
  • Molecular Biology
  • Cell Biology

Background:

  • The envelope glycoprotein M (gM) is a conserved surface protein in alphaherpesviruses.
  • gM is a multi-transmembrane domain glycoprotein with complex N-linked oligosaccharides.
  • gM plays a critical role in various stages of the viral life cycle.

Purpose of the Study:

  • To review the biological characteristics and functions of glycoprotein M (gM).
  • To summarize the role of gM in specific alphaherpesviruses.
  • To discuss recent research on gM interactions and its participation in the viral life cycle.

Main Methods:

  • Literature review of existing studies on alphaherpesvirus glycoprotein M.
  • Analysis of characterized functions of gM in viral invasion, assembly, and egress.
  • Examination of reported interactions between gM and viral/cellular components.

Main Results:

  • gM mediates virus-induced membrane fusion during entry.
  • gM facilitates protein transport for virion envelopment.
  • gM promotes viral egress and interacts with various cellular and viral factors.

Conclusions:

  • Glycoprotein M is essential for multiple critical steps in the alphaherpesvirus life cycle.
  • Understanding gM's functions and interactions is key to comprehending alphaherpesvirus pathogenesis.
  • Further research on gM interactions will elucidate its precise roles in viral replication.
Keywords:
alphaherpesvirusesentryfusionglycoprotein Mthe viral life cycles

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