CCR5 Promoter Polymorphisms Associated With Pulmonary Tuberculosis in a Chinese Han Population.
Shuyuan Liu1, Nannan Liu1, Hui Wang2
1Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.
Frontiers in Immunology
|March 8, 2021
Summary
Genetic variations in the CCR5 gene promoter are linked to tuberculosis susceptibility and progression. Specific CCR5 polymorphisms increase the risk of developing pulmonary tuberculosis and disease recurrence in the Chinese Han population.
Area of Science:
- Immunogenetics
- Infectious Diseases
- Human Genetics
Background:
- Tuberculosis (TB) is a significant global health issue caused by Mycobacterium tuberculosis.
- Chemokine receptors like CCR5 are crucial for immune cell responses against TB.
Purpose of the Study:
- To investigate the association between CCR5 gene promoter variations and tuberculosis infection and progression.
- To analyze the correlation between specific CCR5 polymorphisms and TB susceptibility in a Chinese Han population.
Main Methods:
- A case-control study involving 450 TB patients and 306 healthy controls.
- Sequencing was used to detect polymorphisms in the CCR5 promoter region.
- Logistic regression analysis and stratified analysis were performed.
Main Results:
- The rs2734648-G allele and rs2734648-GG genotype were significantly associated with increased TB susceptibility.
- rs2734648-GG correlated with higher susceptibility to pulmonary TB, and the rs2734648-G allele with TB recurrence.
- A specific haplotype in the CCR5 promoter showed a significantly increased risk for TB and pulmonary TB susceptibility.
Conclusions:
- CCR5 promoter polymorphisms are associated with pulmonary TB and disease progression.
- These findings highlight the role of CCR5 gene variations in TB pathogenesis within the studied population.
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