Related Experiment Video
Updated: Nov 15, 2025
06:07
Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
Published on: March 28, 2025
678
Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways
Julia Blay-Cadanet1, Alice Pedersen1, Christian Kanstrup Holm1
1Department of Biomedicin, Aarhus University, Aarhus, Denmark.
Frontiers in Immunology
|March 8, 2021
Summary
Metabolic reprogramming influences cellular nucleic acid sensing pathways. Metabolites, accumulating during immune responses, act as key regulators of these sensing mechanisms, impacting inflammatory diseases.
Area of Science:
- Immunology
- Metabolism
- Molecular Biology
Background:
- Cellular nucleic acid sensors detect pathogen DNA/RNA, triggering antimicrobial responses.
- Dysregulated sensor activation contributes to inflammatory diseases.
- Metabolic reprogramming in immune cells influences nucleic acid sensing.
Purpose of the Study:
- To review the role of metabolites in regulating nucleic acid sensing pathways.
- To highlight the connection between metabolic reprogramming and immune responses.
Main Methods:
- Literature review of recent studies on nucleic acid sensing and metabolism.
- Analysis of how metabolic pathways impact immune cell function.
Main Results:
- Metabolites are increasingly recognized as regulators of nucleic acid sensing.
- Metabolic reprogramming alters metabolite levels, affecting immune signaling.
- Pathogen-associated molecular patterns induce metabolic changes impacting sensing.
Conclusions:
- Metabolites play a crucial role in controlling nucleic acid sensing.
- Understanding this interplay is vital for managing inflammatory conditions.
- Metabolic pathways are key targets for modulating immune responses.
Related Concept Videos
01:28Biosynthesis of Nucleic Acids
518
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
518
01:19Regulation of Metabolism
10.7K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
10.7K
01:45Regulation of Nuclear Protein Sorting
2.9K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.9K
01:26Signal Transduction: Overview
10.4K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Typically, signal transduction involves three...
10.4K
01:56Riboswitches
9.0K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
9.0K
01:28Global Regulatory Systems
319
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
319