Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

518
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
518
Regulation of Metabolism01:19

Regulation of Metabolism

10.7K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
10.7K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

2.9K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.9K
Signal Transduction: Overview01:26

Signal Transduction: Overview

10.4K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
10.4K
Riboswitches01:56

Riboswitches

9.0K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
9.0K
Global Regulatory Systems01:28

Global Regulatory Systems

319
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
319

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The potential effectiveness of far-UVC (222 nm) in preventing infections in long-term care facilities: a six-month nonrandomized controlled phase II trial.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

MAVS is important for antiviral defense against influenza A virus in a human respiratory epithelium model.

PloS one·2026
Same author

NRF2 controls a diverse network of antiviral effectors with p62 acting as a central restriction factor effective across virus families.

Redox biology·2026
Same author

Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2.

Nature communications·2025
Same author

STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor.

Nature immunology·2025

Related Experiment Video

Updated: Nov 15, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

678

Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways.

Julia Blay-Cadanet1, Alice Pedersen1, Christian Kanstrup Holm1

  • 1Department of Biomedicin, Aarhus University, Aarhus, Denmark.

Frontiers in Immunology
|March 8, 2021
PubMed
Summary

Metabolic reprogramming influences cellular nucleic acid sensing pathways. Metabolites, accumulating during immune responses, act as key regulators of these sensing mechanisms, impacting inflammatory diseases.

Keywords:
MAVSSTINGitaconatelactatemetabolitessuccinatetoll-like receptors

More Related Videos

Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.2K
Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

9.1K

Related Experiment Videos

Last Updated: Nov 15, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

678
Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.2K
Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

9.1K

Area of Science:

  • Immunology
  • Metabolism
  • Molecular Biology

Background:

  • Cellular nucleic acid sensors detect pathogen DNA/RNA, triggering antimicrobial responses.
  • Dysregulated sensor activation contributes to inflammatory diseases.
  • Metabolic reprogramming in immune cells influences nucleic acid sensing.

Purpose of the Study:

  • To review the role of metabolites in regulating nucleic acid sensing pathways.
  • To highlight the connection between metabolic reprogramming and immune responses.

Main Methods:

  • Literature review of recent studies on nucleic acid sensing and metabolism.
  • Analysis of how metabolic pathways impact immune cell function.

Main Results:

  • Metabolites are increasingly recognized as regulators of nucleic acid sensing.
  • Metabolic reprogramming alters metabolite levels, affecting immune signaling.
  • Pathogen-associated molecular patterns induce metabolic changes impacting sensing.

Conclusions:

  • Metabolites play a crucial role in controlling nucleic acid sensing.
  • Understanding this interplay is vital for managing inflammatory conditions.
  • Metabolic pathways are key targets for modulating immune responses.