Related Experiment Video
Updated: Nov 15, 2025

Investigation of Plant Interactions Across Common Mycorrhizal Networks Using Rotated Cores
Published on: March 26, 2019
Network Topological Analysis for the Identification of Novel Hubs in Plant Nutrition
Dario Di Silvestre1, Gianpiero Vigani2, Pierluigi Mauri1
1Proteomic and Metabolomic Laboratory, ITB-CNR, Segrate, Italy.
Abstract:
Network analysis is a systems biology-oriented approach based on graph theory that has been recently adopted in various fields of life sciences. Starting from mitochondrial proteomes purified from roots of Cucumis sativus plants grown under single or combined iron (Fe) and molybdenum (Mo) starvation, we reconstructed and analyzed at the topological level the protein-protein interaction (PPI) and co-expression networks. Besides formate dehydrogenase (FDH), already known to be involved in Fe and Mo nutrition, other potential mitochondrial hubs of Fe and Mo homeostasis could be identified, such as the voltage-dependent anion channel VDAC4, the beta-cyanoalanine synthase/cysteine synthase CYSC1, the aldehyde dehydrogenase ALDH2B7, and the fumaryl acetoacetate hydrolase. Network topological analysis, applied to plant proteomes profiled in different single or combined nutritional conditions, can therefore assist in identifying novel players involved in multiple homeostatic interactions.
Related Concept Videos
Key Elements for Plant Nutrition
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Short-distance Transport of Resources
The Roles of Bacteria and Fungi in Plant Nutrition
Water and Mineral Acquisition
Cell Signaling in Plants

