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The effect of acute complicated appendicitis on liver function test.

Kulsoom MoulaBux1, Sughra Parveen2, Mazhar Iqbal3

  • 1Dr. Kulsoom MoulaBux, MBBS, FCPS-I. Department of General Surgery, Ward-3, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

Pakistan Journal of Medical Sciences
|March 8, 2021
PubMed
Summary

Hyperbilirubinemia is a strong indicator for diagnosing complicated appendicitis, including suppurative and gangrenous forms. This finding aids in early detection and management of acute appendicitis.

Keywords:
Gangrenous appendicitisHyperbilirubinemiaSuppurative appendicitis

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Area of Science:

  • Medical Diagnostics
  • Gastroenterology
  • Surgical Pathology

Background:

  • Acute appendicitis remains a common surgical emergency.
  • Distinguishing between simple and complicated appendicitis (suppurative, gangrenous) is crucial for patient outcomes.
  • Diagnostic challenges exist, necessitating reliable biomarkers.

Purpose of the Study:

  • To evaluate the diagnostic utility of hyperbilirubinemia in acute appendicitis.
  • To correlate hyperbilirubinemia levels with the severity of appendicitis, specifically suppurative and gangrenous forms.

Main Methods:

  • An observational study involving 120 patients undergoing appendectomy.
  • Serum liver function tests and leukocyte counts were analyzed.
  • Operative findings and histopathology confirmed appendicitis stages and correlated with hyperbilirubinemia.

Main Results:

  • Hyperbilirubinemia was present in 100% of gangrenous and 94.12% of suppurative appendicitis cases.
  • Elevated Alanine transaminase and Aspartate transaminase levels were observed in 50% of complicated cases.
  • Elevated total leukocyte count (TLC) was noted in 96.55% of patients.

Conclusions:

  • Hyperbilirubinemia serves as a significant diagnostic predictor for complicated appendicitis.
  • The presence of elevated bilirubin levels warrants further investigation for severe appendicitis forms.
  • This biomarker can potentially improve diagnostic accuracy in acute appendicitis.