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Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
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The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases

Jinlin Liu1, Li Zhong1,2, Rui Guo1

  • 1College of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China.

Oxidative Medicine and Cellular Longevity
|March 8, 2021
PubMed

Insights

Cardiovascular diseases (CVDs) are linked to mitochondrial dysfunction. This review explores how posttranslational modifications (PTMs) impact mitochondrial quality control, offering insights into CVD mechanisms and potential treatments.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular disease (CVD) remains the leading global cause of mortality.
  • The precise pathogenesis of CVDs is still debated despite extensive research.
  • Mitochondrial homeostasis is crucial for cardiovascular system function.

Purpose of the Study:

  • To review the role of posttranslational modifications (PTMs) in regulating mitochondrial quality control.
  • To explore how PTMs influence the development of cardiovascular diseases (CVDs).
  • To provide insights into potential therapeutic strategies for CVDs.

Main Methods:

  • Literature review of common and novel posttranslational modifications (PTMs).
  • Analysis of PTMs' impact on mitochondrial quality control mechanisms.
  • Synthesis of current understanding of PTMs in cardiovascular disease (CVD) pathogenesis.

Main Results:

  • Alterations in mitochondrial protein function can lead to dysfunction and CVDs.
  • Posttranslational modifications (PTMs) reversibly alter protein conformation and function.
  • Specific PTMs are implicated in regulating mitochondrial quality control pathways relevant to CVDs.

Conclusions:

  • Posttranslational modifications (PTMs) are critical regulators of mitochondrial quality control in the context of cardiovascular disease (CVD).
  • Understanding PTMs offers new avenues for investigating CVD mechanisms.
  • Targeting PTMs presents potential therapeutic opportunities for cardiovascular diseases (CVDs).

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