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Updated: Nov 15, 2025

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells
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KRAS and BRAF mutations in Iranian colorectal cancer patients: A systematic review and meta-analysis

Abolfazl Yari1,2, Asiyeh Afzali3, Mostafa Aalipour4

  • 1Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.

Caspian Journal of Internal Medicine
|March 8, 2021
PubMed
Abstract

Insights

This meta-analysis found KRAS mutations in 33.9% and BRAF mutations in 3.2% of Iranian colorectal cancer (CRC) patients. These gene mutations significantly impact CRC treatment strategies and patient prognosis.

Area of Science:

  • Oncology
  • Genetics
  • Epidemiology

Background:

  • Mutations in the Epidermal Growth Factor Receptor (EGFR) signaling pathway are crucial in colorectal cancer (CRC) development.
  • KRAS and BRAF gene mutations influence CRC treatment, prognosis, and resistance to anti-EGFR therapies.

Purpose of the Study:

  • To systematically analyze and meta-analyze the prevalence of KRAS and BRAF gene mutations in Iranian CRC patients.
  • To provide a comprehensive overview of mutation frequencies in this specific population.

Main Methods:

  • A systematic search of four major databases (MEDLINE, EMBASE, Web of Science, Cochrane) and local Iranian databases up to March 2018.
  • Data extraction and quality assessment by two independent reviewers, with meta-regression used to explore heterogeneity.

Main Results:

  • Included 23 studies with 2662 CRC patients.
  • Prevalence of KRAS mutations was 33.9% (codon 12 and 13: 76.9% and 23.5% respectively).
  • BRAF mutation rate was 3.2%.

Conclusions:

  • Significant regional variations in mutation prevalence across Iran suggest environmental and racial factors.
  • Understanding these mutation frequencies is vital for tailoring CRC treatment in Iran.
Keywords:
BRAFCRCColorectal cancerIranKRASMutation

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