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Association of platelet count and mean platelet volume (MPV) index with types of stroke
Bahram Zarmehri1, Behzad Shahi1, Shaghayegh Rahmani1
1Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
Mean platelet volume (MPV) may predict stroke type. Higher MPV is linked to hemorrhagic stroke, potentially aiding early diagnosis and understanding platelet roles in stroke development.
Area of Science:
- Neurology
- Hematology
- Medical Diagnostics
Background:
- Stroke is a leading cause of death and disability globally.
- Investigating predictive markers for stroke subtypes is crucial for patient management.
Purpose of the Study:
- To examine the association between platelet count (PC) and mean platelet volume (MPV) with different stroke types.
- To determine if MPV can serve as a predictor for hemorrhagic versus ischemic stroke.
Main Methods:
- A cross-sectional study included 150 adult patients with acute stroke symptoms.
- Exclusion criteria included chronic conditions and delayed presentation (>6 hours).
- Complete blood cell count (CBC) was performed, analyzing PC and MPV.
Main Results:
- The study comprised 150 patients (54.7% male).
- CT scans revealed brain infarction in 56% and intracranial hemorrhage in 35.3% of patients.
- Intracranial hemorrhage patients showed significantly higher MPV than those with infarction or normal scans (p<0.001).
Conclusions:
- MPV index can predict hemorrhagic or ischemic findings on emergency CT scans in stroke patients.
- This association may illuminate platelet pathophysiology in stroke.
- MPV is a potential diagnostic aid but does not replace CT for stroke diagnosis or treatment initiation.
Background:
Stroke is known to be the third most prominent cause of death in the developing countries and the most common debilitating neurologic disease. This study aimed to investigate the association of platelet count (PC) and mean platelet volume (MPV) index with various stroke types.
Methods:
This cross-sectional study was carried out on patients over the age of 18 years who presented with signs and symptoms of the first acute stroke. Exclusion criteria were underlying chronic liver or renal disease and the time more than 6 hours from symptom initiation, hematological and infectious disorders in patients. After recording of demographic data, a complete blood cell count (CBC) test was performed.
Results:
From 150 patients, who enrolled in the study, 54.7% of patients were males. The initial brain CT scan was normal in 13 (8.7%) patients and showed evidence of brain infarction and intracranial hemorrhage in 84 (56%) and 53 (35.3%) patients respectively. Patients with intracranial hemorrhage had significantly higher mean of MPV index than the patients with normal brain-CT scan and patients with evidence of brain infarction (p<0.001).
Conclusion:
The MVP index can be a predictor of the type of hemorrhagic or ischemic finding in emergency CT scan in stroke patients. This relationship may help to better understand the physiopathologic role of platelets in the development of stroke (hemorrhagic or ischemic), but will not replace cerebral computed tomography to diagnose the type of stroke, or it may not initiate treatment for hemorrhagic stroke.
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