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Submucosal urothelial bladder cancer: A case report.
Fusako Niimi1, Tetsuya Danno1, Shohei Iwata1
1Department of Urology, Tokyo Metropolitan Tama Medical Center, Fuchu, Tokyo 183-0042, Japan.
Molecular and Clinical Oncology
|March 8, 2021
Summary
This report details the first documented case of submucosal urothelial cancer, a rare bladder tumor. Early consideration of bladder cancer is crucial even with submucosal tumors and no prior history.
Area of Science:
- Uro-oncology
- Surgical pathology
Background:
- Bladder tumors are predominantly of epithelial origin, with urothelial carcinomas accounting for 90% of cases.
- Mesodermal tumors are rare, with leiomyomas being the most common, and their prognosis varies with histology.
- Urothelial cancer typically arises from the bladder epithelium, not the submucosa.
Purpose of the Study:
- To report the first case of submucosal urothelial cancer.
- To discuss potential pathomechanisms and diagnostic considerations for this rare presentation.
Main Methods:
- Case report of a patient diagnosed with submucosal urothelial cancer.
- Diagnosis confirmed via transurethral resection of bladder tumor (TURBT).
Main Results:
- A unique case of submucosal urothelial cancer was identified in a patient with no prior bladder cancer history.
- Two hypotheses for its development include intra-diverticular origin or aberrant submucosal urothelium.
- Prognosis may be poor if originating in a diverticulum, similar to invasive bladder cancer.
Conclusions:
- Submucosal urothelial cancer is a rare entity, with this being the first reported case.
- Differential diagnosis for submucosal bladder tumors should include urothelial cancer, regardless of prior history.
- The diagnostic challenge highlights the importance of TURBT for accurate pathological assessment.
